Neuro Plus Brain and Focus

Vitamin A

• May support vision health, skin health, immune health, and increases antioxidant support (182, 183).
• May support antioxidant function via decreased inflammatory cytokines (inflammation), decreased reactive oxygen species, and increased L-glutathione production (master antioxidant) (182, 183).
• May support visual health via increased amounts of plasma vitamin A in macular (eye) tissues (182,183).

Vitamin C

• May support immune, cardiovascular, skin, cognitive, fat burning, and digestive health (97, 98).
• May support immune health via increased oxidant, free radical scavenging, and fueling neutrophilic (immune cell) activity in chemotaxis, phagocytosis, and microbial killing (97,98).
• May support fat burning by increasing carnitine biosynthesis (molecule required for mitochondrial fatty acid oxidation) (97,98).
• May support accelerated bone healing after a fracture, increased type I collagen synthesis, and reduced oxidative stress (inflammation) (98).

Vitamin D

• May support exercise performance, immune health, muscle growth, optimal bone health, hormonal health, immune function, increased sexual health, cardiovascular health, glucose tolerance,  increased strength, and positive mood (77,78,79).
• May support hormonal health via high amounts of vitamin D receptor (VDR) activity in hormone based negative feedback loop reactions (77,78).
• May support cardiovascular health via improved absorption of calcium, reduced atherosclerotic activity, stimulating cardiomyocytes, and improved vascular health (77,78).
• May support exercise recovery via reduced post exercise inflammation and muscle damage (77,78).
• May support sexual health via increased activity of Vitamin D receptor activity of testosterone production (79).
• May support immune function via decreases of inflammatory cytokines and aiding immune cells (77,78).
• May support joint health via regulating calcium and phosphorus and bone remodeling along with other calcium-regulating actions (77,78).

Vitamin E

• May support immune function, cognitive health, cardiovascular health, and bone health (204,205,206,207,208)
• May support immune health via neutralizing free radicals and reactive oxygen species, and increased T lymphocyte-mediated immune function (204).
• May support cardiovascular health via reduced cholesterol (204).
• May support cognitive function via reduced oxidative stress, inflammation, and DNA damage of neuronal tissues (208).

Vitamin B1 (Thiamine)

• May support aerobic energy metabolism (oxidative phosphorylation), cell growth, optimal neuronal conduction (nerve impulses), and cardiovascular health (94).
• May support cardiovascular function and aids as a neuroprotective agent in individuals with vitamin B-1 deficiencies (94, 95). 

Vitamin B2 (Riboflavin)

• May support conversion and activation of other B vitamins, red blood cell production and serves as a cofactor for both glucose and fat metabolism (energy production) (92,93).

Vitamin B3 (Niacin)

• Major B vitamin that may support cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reducing very-low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (9).
• Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9).
• Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9).
• May support healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (9).
• May support reduced prevalence of pellagra, nervous anorexia, and Crohn’s disease (10, 11).

Vitamin B6

• Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40).
• May support reduced plasma glucose (blood sugar levels) via inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39).
• Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40).
• May support blood sugar regulation in women with gestational diabetes (40).
• Cofactor for enzymes involved in DNA metabolism (40).

Biotin

• May support proper cell growth and DNA synthesis (65).
• May support conversion of food into cellular energy, hair health, skin health, and cognitive function (213,214).
• May support glucose breakdown into skeletal muscle tissue (213,214).

Vitamin B5

• May support energy production, cell growth, cell repair, cognitive function, increased hippocampal volume (memory), and optimized bioenergetics (burning of carbohydrates, fat, and protein) (96).

Calcium

• May support bone health, muscle function, and cardiovascular health (36,37).
•  Regulates processes of bone resorption, mineralization, and fracture repair (36,37).
• Increases the effect of physical exercise on bone mineral acquisition in the period preceding puberty (36,37).
• May support reduced prevalence of preeclampsia (36,37).

Iron

• May support  red blood cell formation, immune function, and antioxidant support (215,216).
• May support increased oxygen uptake into red blood cells of Iron deficient individuals (215,216).
• May support gut health of iron-deficient individuals.
• May support reduced prevalence of anemia in Iron deficient individuals (217).

Magnesium

• May support optimal nerve function, muscle contractions, cardiovascular, bone health, and decreased anxiety (90,91).
• Supports biological reactions such as ATP-fueled reactions and pancreatic insulin secretion (90,91).
• May support reduced systolic blood pressure, fasting glucose, triglycerides, and healthy HDL levels (90,91).
• May support reduced peripheral cortisol levels in the CNS and supports relaxation and decreased anxiety (90,91).

Zinc

• May support immune function, skin health, cognitive function, and vision (172,173).
• May support stimulation of the innate and adaptive immune system (172,173).
• May support the activation of lymphocytes and activation of innate and T cell-mediated immunity (172,173).
• May support cognitive function by modulation of neuronal signaling in areas of the brain associated with memory and learning (hippocampus) (172,173).

Selenium

• May support antioxidant function, cardiovascular health, cognitive function, thyroid health, and immune health (145, 146).
• May support reduced prevelance of atherosclerosis, high cholesterol (hypercholesterolemia), and type 1 diabetes (147).
• May support thyroid health via decreased circulating thyroid autoantibodies in patients with chronic autoimmune thyroiditis (AIT) (146).
• Increases the activity of selenoproteins that decrease reactive oxygen species (inflammation), increases natural killer activity, and increases glutathione (master antioxidant) levels (145,147)May support antioxidant function, cardiovascular health, cognitive function, thyroid health, and immune health (145, 146).
• May support reduced prevelance of atherosclerosis, high cholesterol (hypercholesterolemia), and type 1 diabetes (147).
• May support thyroid health via decreased circulating thyroid autoantibodies in patients with chronic autoimmune thyroiditis (AIT) (146).
• Increases the activity of selenoproteins that decrease reactive oxygen species (inflammation), increases natural killer activity, and increases glutathione (master antioxidant) levels (145,147)

Copper

• May support healthy blood sugar levels, energy metabolism and cholesterol management (143,144)

Manganes

• May support enzymatic antioxidant reactions, increased bone mineral density, and blood sugar regulation (148,149).

Chromium

• May support insulin function, reduced cholesterol, improved blood sugar regulation, and may lower cholesterol (218,219).