Calcium Carbonate
May support bone health, muscle function, and cardiovascular health (36,37)
Regulates processes of bone resorption, mineralization, and fracture repair (36,37).
Increases the effect of physical exercise on bone mineral acquisition in the period preceding puberty (36,37).
May support reduced prevalence of preeclampsia (36,37).
Vitamin B6
Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40)
May support reduced plasma glucose (blood sugar levels) via inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39).
Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40).
May support blood sugar regulation in women with gestational diabetes (40).
Cofactor for enzymes involved in DNA metabolism (40).
Magnesium
May support optimal nerve function, muscle contractions, cardiovascular, bone health, and decreased anxiety (90,91).
Supports biological reactions such as ATP-fueled reactions and pancreatic insulin secretion (90,91).
May support reduced systolic blood pressure, fasting glucose, triglycerides, and healthy HDL levels (90,91).
May support reduced peripheral cortisol levels in the CNS and supports relaxation and decreased anxiety (90,91).
L-Tryptophan
May support decreased anxiety, positive mood, improved gut brain axis cross talk, and an improved sleep cycle (259,260).
Decreases anxiety via increases in 5 HTP (259, 260).
May support improved circadian rhythm via increased natural melatonin production (259,260).
May support gut brain axis via natural increased production of serotonin in gut neurons (260).
Goji Berry
May support immune health, vision health, immune health, and aids as a neuroprotective agent (261,262).
May support immune function via carotenoid and polyphenolic free radical scavenging capabilities, reduced DNA damage, and reduced inflammatory cytokines (261).
May support vision health via ocular neuroprotective effects zeaxanthin content (found in goji berry) (262).
May support cognitive function via increased neuronal protection with potent ameliorative effects on neuronal oxidative stress, inflammation, apoptosis and neuronal cell death (262).
Chamomile
May support healthy sleep, relaxation, reduced anxiety, and antioxidant support (251,252,253).
May support antioxidant function due to high levels of quercetin (flavonoid antioxidant) (251,252,253).
May support sleep via increases in parasympathetic (relaxation mode) activity, increased benzodiazepine-like hypnotic activity (sleep inducer), and attachment to GABA receptors (251,252,253).
Lemon Balm
May support healthy sleep, relaxation, reduced anxiety, and antioxidant support (254,255).
May support antioxidant function via ability to scavenge free radicals, reduce oxidative stress, increased glutathione production (master antioxidant) combat DNA damage (254,225).
May support relaxed sleep via enhanced REM cycles reduced stress at bedtime (254,225).
Passion Flower
May support reduced stress, enhanced sleep, and improved mood (248).
May support positive mood and improved sleep via regulated gamma‐aminobutyric acid receptor A (GABAA) activity (receptor which controls sleep) (248).
L-Taurine
May support hydration, increased energy, antioxidant function, and increases fat metabolism during aerobic exercise (242,243).
May support antioxidant function via combating reactive oxygen species (243).
May support increased fat metabolism during exercise via enhanced mitochondrial fatty acid oxidation (cells using fat as fuel) (242).
Hops
May support reduced prevalence of depression, anxiety, reduced triglycerides and increased positive mood (246,247).
St. John’s Wort
May support reduced depression and increased positive mood (249,250).
GABA
May support relaxation, positive mood, increased memory, reduced anxiety, blood sugar regulation, and increased growth hormone production (102).
Skullcap
May support calming mood and relaxation.
L-Theanine
Unique non-protein amino acid found in green tea (Camellia sinensis) (53).
May support mood, mental clarity, and cognitive health, memory, and is a natural anti-depressant/neuroprotective agent (53).
Ashwagandha
May support cardiovascular, hormonal, immune, healthy weight loss, mood, and optimized sleep (82,83).
May support reduced stress hormone cortisol resulting in improved body composition, sex hormone profile, and mood (82,83).
May support improved exercise performance via increased V02 max, muscular endurance, muscle hypertrophy (muscle growth), and decreased muscular fatigue (83).
May support improved quality of sleep by enhancing sleep recovery, reducing plasma cortisol concentrations, and enhancing REM sleep cycles (83).
May support hormonal and immune health via reduced production of inflammatory molecules (reactive oxygen species) and simultaneous increases in sex hormones (84).
Inositol
May support liver detoxification, reduced prevalence of metabolic syndrome, and aids as an antioxidant (221).
May support reduced prevalence of metabolic syndrome via reduced levels of triglycerides, total- and LDL-cholesterol (221).
May support antioxidant function via reduced levels of reactive oxygen species and inflammatory markers (interleukin 6) (222).
5-HTP
May support healthy sleep patterns, mood, reduced anxiety, and supports the gut brain axis (261).
May support healthy sleep patterns via enhanced circadian rhythm and increased natural melatonin production (261).
May support gut brain axis via natural increased production of serotonin (neurotransmitter) in gut neurons (260, 261).
Melatonin
May support healthy sleep patterns, immune function, and antioxidant support (256,257, 258).
May support healthy circadian rhythms, and improves the onset, duration, and quality of sleep.
May support immune function via improved free radical scavenging capacity (258).
Valerian Root
May support reduced stress, enhanced sleep, and improved mood (244,245).
May support enhanced positive mood and sleep via regulated gamma‐aminobutyric acid receptor A (GABAA) activity (receptor which controls sleep) (244, 245).
